Tuesday, January 29, 2013

New Treatments For BPD an Easy to Understand Detailed Overview (2012-2013) Part 2

*2012 Video update Coming Soon!* It will include the latest scientific info from review papers on RCTs on drugs & therapies for BPD (more recent than Wikipedia,which I plan to update after I've finished the video) You can subscribe to my YouTube to know when I've uploaded it http://www.youtube.com/user/ROMI1AAT
But here is a sneak preview while I'm finishing


Showed large, statistically significant effects in the reduction of affective instability impulsivity and interpersonal problems.ITP-BPD is a modified version of Interpersonal Psychotherapy (IPT) which is a brief and very structured manual-based therapy that addresses relationship problemsPatients are encouraged to learn interpersonal skills and adapt their behaviour to current roles and situations.


Dynamic Deconstructive Psychotherapy (DDP)

is a type of psychodynamic psychotherapy used to treat BPD and other complex behavior problems such as drug dependence,self-harm, eating disorders, recurrent suicide attempts & co-occurring disorders,such as substance use disorders or additional personality disorders.
Weekly 1-hour individual sessions over 12 to 18 months

There were no statistically significant results when compared to a therapy control.Encouraging effects on core BPD & associated pathology were found, showing  that it may help severely ill patients.
In Conclusion
Disorder-specific treatments should be used.
Nonspecific treatments that were investigated:Cognitive Behavioural Therapy (CBT), Client-Centered Therapy (CCT), Interpersonal Psychotherapy (IPT) showed no encouraging effects for the treatment of BPD core pathology. The best length of treatment is unclear Based on the available findings, a treatment of 12 to 18 months seems to be appropriate.

Yi-gan san for the treatment of borderline personality disorder: an open-label study.

Recent studies indicate that the traditional Chinese herbal medicine yi-gan san (YGS, yokukan-san in Japanese) may be safe and useful in treating behavioral and psychological symptoms in dementia patients. We aimed at evaluating both efficacy and safety of yi-gan san in patients with well-defined BPD.
Twenty female outpatients diagnosed with BPD according to DSM-IV criteria and the revised Diagnostic Interview for Borderlinescompleted a 12-week open-label study with yi-gan san at an average daily dosage of 6.4+/-1.9 g (2.5-7.5 g). Psychometric instruments to assess efficacy included the Brief Psychiatric Rating Scale (BPRS), Hamilton Rating Scales for Depression (HAM-D), Global Assessment of Functioning (GAF), Clinical Global Impression Scale (CGI), and Aggression Questionnaire (AQ).Most psychometric scale scores exhibited a highly significant improvement (total BPRS; BPRS
somatic concern, anxiety, tension,depressive mood, hostility, suspiciousness, motor retardation, uncooperativeness,and excitement subscale; CGI; GAF; AQ) over time.
In this open-label pilot study, patients treated with YGS showed statistically significant reduction on self-rated and clinician-rated scales. The present findings suggest that yi-gan san might be effective for the treatment of a number of BPD symptoms, including low mood, impulsivity, and aggression.


Omega-3 Fatty acid treatment of women with borderline personality disorder: a double-blind, placebo-controlled pilot study.

The purpose of this study was to compare the efficacy of ethyl-eicosapentaenoic acid (E-EPA) and placebo in the treatment of female subjects with borderline personality disorder.
Method:The authors conducted an 8-week, placebo-controlled, double-blind study of E-EPA in 30 female subjects meeting Revised Diagnostic Interview for Borderlines and DSM-IV criteria for borderline personality disorder.
Twenty subjects were randomly assigned to 1 g of E-EPA; 10 subjects were given placebo. Ninety percent of those in both groups completed all 8 weeks of the trial. Analyses that used random-effects regression modeling and controlled for baseline severity showed E-EPA to be superior to placebo in diminishing aggression as well as the severity of depressive symptoms.
Conclusions:The results of this study suggest that E-EPA may be a safe and effective form of monotherapy for women with moderately severe borderline personality disorder.

St John's Wort and 5HTP

St John's Wort Hypericum perforatum 5-Hydroxytryptophan 5HTP BPD borderline personality disorder depression natural remedies symptom 5HTP
Some borderlines have found a combination or 1 to be helpful,no studies have been done unfortunately.You should not take either with other meds especially antidepressants and at too high doses as serious damage can result,you should also not be taking them with alcohol and side effects may occur... Consult your doctor as always when starting any treatment...St John's Wort is not appropriate for severe depression.

I have a condition known as BPD or Borderline Personality Disorder and I have found that taking both SJW and 5-HTP has really helped me by levelling my mood swings, regulating my sleep patterns, reducing the feelings of stress, depression and anger. I've been taking these for well over a year with no side effects, I sometimes miss taking then for a week and I notice that my symptoms start to slowly return but not in a worse way and once I start again, after about a week I feel back to "normal".

 I am now well into my recovery, and exclusively on St. John's Wort. I have been taking SJW by itself for around a year, and also recently tested 1 month of total withdrawl from it. After the test, I confirmed the SJW is having a very positive affect on my life. The only real side-effect I have is photosensitivity, especially to bright flourescent lighting in buildings. Well bright artificial light in general. Sunlight doesn't really bother me so much, but then again I'm usually indoors anyway

A further discussion of it can be found here http://www.psychforums.com/borderline-personality/topic41988.html

Energy Psychology Work 
Not yet proven/studied much,but something to look into.

Lists of  other treatments may be found here: http://en.wikipedia.org/wiki/Management_of_borderline_personality_disorder

limbic,system,amygdala,fear,emotion, hippo-campus,parahippocampal,gyrus,fornix,cingulate,gyrus,mental disorder,abnormal,brain structure,size,grey matter,brain.pychology,borderline personality disorder,BPD,emotional unstable personality disorder,emotionally
Click to enlarge

brain borderline personality disorder BPD neurotransmitter stress ventral striatum,prefrontal,cortex,amygdala,ventromedial,subgenual cingulate,medial,hippocampus,limbic,fight or flight
Brain Regions are appproximate

grey matter,white,axon,dendrite,cell body,synapse,neurotransmitters,impulse,nerve

I have written a post you might find useful,it contains some information on low cost/free workshops for family & people that suffer from mental illnesses Can't Afford Treatment/Want to Further Research ?

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